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Lung cancer drug resistance explained by computer simulations

Lung cancer drug resistance explained by computer simulations

Scientists from the Universities of Bristol and Parma, Italy, have used molecular simulations to understand resistance to osimertinib — an anticancer drug used to treat types of lung cancer. Osimertinib binds tightly to a protein, epidermal growth factor receptor (EGFR), which is overexpressed in many tumours. EGFR is involved in a pathway that signals for […]

Light-activated Cancer Drugs Without Toxic Side Effects: Fresh Insight

Light-activated Cancer Drugs Without Toxic Side Effects: Fresh Insight

Future cancer drugs that are activated by light and don’t cause the toxic side-effects of current chemotherapy treatments are closer to becoming a reality, thanks to new research made possible by the Monash Warwick Alliance, an intercontinental collaboration between the University of Warwick (UK) and Monash University (Australia). Led by Robbin Vernooij, a joint PhD […]

Scientists are combining drugs and radiotherapy, hunting for better results

Scientists are combining drugs and radiotherapy, hunting for better results

Radiotherapy has been around for decades, and is often extremely effective. But researchers are still discovering new ways to use it. This includes testing new drugs alongside radiotherapy. “The aim is to increase the chance of a cure by making the radiotherapy more effective at killing cancer cells,” says Professor Anthony Chalmers, a Cancer Research UK-funded […]

Prostate Cancer: Hypofractionated Radiotherapy’s Role in Post-operative Settings

Prostate Cancer: Hypofractionated Radiotherapy’s Role in Post-operative Settings

Hypofractionated external beam radiotherapy (EBRT) delivers the total prescribed therapeutic radiation dose in fewer, larger-dose fractions than standard radiotherapy dose schedules, accelerating treatment time. “The key advantages of moderate hypofractionation, owing to its shorter treatment courses, are lower cost and greater convenience for patients,” said Scott Morgan, MD, assistant professor of radiation oncology at the University […]

How Cancer Metastasis Happens: Researchers Reveal a Key Mechanism

How Cancer Metastasis Happens: Researchers Reveal a Key Mechanism

Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center researchers. How metastasis occurs has been one of the central mysteries […]

Remote-controlled cancer immunotherapy system

Remote-controlled cancer immunotherapy system

A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells. There is a critical need to non-invasively and remotely manipulate cells at a distance, particularly for translational applications in animals and humans, researchers said. The […]

Focused Radiation May Nearly Erase Ventricular Tachycardia

Focused Radiation May Nearly Erase Ventricular Tachycardia

Ablation for ventricular tachycardia may be achieved by noninvasive means with cardiac radiation, a case series showed. The catheter-free radioablation technique used by Phillip Cuculich, MD, of Washington University School of Medicine in St. Louis, and colleagues resulted in a 99.9% reduction of ventricular tachycardia episodes among five study subjects, as recorded by implantable cardioverter-defibrillators (ICDs). Participants […]

Unravelling the mystery of radiotherapy

Unravelling the mystery of radiotherapy

Cancer treatment and care has made enormous progress over recent years, with a significant improvement in survival rates and quality of life after cancer. Much of this is down to the evolution of radiation therapy. Around four in ten of all NHS cancer patients are treated with radiotherapy and last year Simon Stevens, chief executive […]

More than just ‘chemo brain’: Cancer impacts memory, too

More than just ‘chemo brain’: Cancer impacts memory, too

People undergoing cancer treatment often report experiencing “chemo brain,” or states of confusion and cognitive impairment due to aggressive chemotherapy treatment. But new research suggests that these cognitive problems might start earlier, with the development of cancer tumors. Researchers at the Baycrest Centre for Geriatric Care in Toronto, Canada, conducted a study focusing on the […]

Researchers Build a Cancer Immunotherapy Without Immune Cells

Researchers Build a Cancer Immunotherapy Without Immune Cells

Engineering an immune cell to recognize and kill a cancer cell is the key to chimeric antigen receptor (CAR) T-cell therapy, but modified immune cells also have the potential to cause problems for patients. One such complication, cytokine release syndrome, is an overreaction of the immune system that can cause symptoms as mild as a fever […]

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