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Researchers Build a Cancer Immunotherapy Without Immune Cells

Researchers Build a Cancer Immunotherapy Without Immune Cells

Engineering an immune cell to recognize and kill a cancer cell is the key to chimeric antigen receptor (CAR) T-cell therapy, but modified immune cells also have the potential to cause problems for patients. One such complication, cytokine release syndrome, is an overreaction of the immune system that can cause symptoms as mild as a fever […]

Has the Safety and Efficacy of Radiotherapy Improved?

Has the Safety and Efficacy of Radiotherapy Improved?

A recent review evaluated advances which surround the use of radiotherapy to treat cancer patients and the impact they have on patient safety. The History of Radiotherapy With over an estimated 14.7 million people in the US living with cancer (2014 statistics), at least half of these patients will receive radiotherapy. Improvements in diagnosis, supportive […]

Gut microbiome may make chemo drug toxic to patients

Gut microbiome may make chemo drug toxic to patients

Albert Einstein College of Medicine researchers report that the composition of people’s gut bacteria may explain why some of them suffer life-threatening reactions after taking a key drug for treating metastatic colorectal cancer. The findings, described online in npj Biofilms and Microbiomes, a Nature research journal, could help predict which patients will suffer side effects and […]

Gut bacteria ‘boost’ cancer therapy

Gut bacteria ‘boost’ cancer therapy

Bacteria living in the murky depths of the digestive system seem to influence whether tumors shrink during cancer therapy, say French and US researchers. They tested the microbiome – the collection of microscopic species that live in us – in cancer patients. Two studies, in the journal Science, linked specific species and the overall diversity […]

How bacteria hinder chemotherapy

How bacteria hinder chemotherapy

To the reasons that chemotherapy sometimes does not work, we can now add one more: bacteria. In a study published in Science, researchers describe findings that certain bacteria can be found in human pancreatic tumors. The findings further showed that some of these bacteria contain an enzyme that inactivates a common drug used to treat various […]

Promising immunotherapy drug now available for some lung cancer patients in England

Promising immunotherapy drug now available for some lung cancer patients in England

Some lung cancer patients in England can now be offered a potentially life-extending immunotherapy drug. The National Institute for Health and Care Excellence (NICE) has said that nivolumab (Opdivo) should be made available to certain lung cancer patients in England through the Cancer Drugs Fund (CDF). Rose Gray, Cancer Research UK’s senior policy adviser, welcomed the decision […]

Chemo-boosting drug discovered for leukaemia

Chemo-boosting drug discovered for leukaemia

Drugs developed to treat heart and blood vessel problems could be used in combination with chemotherapy to treat an aggressive form of adult leukaemia. Researchers at the Francis Crick Institute, King’s College London and Barts Cancer Institute discovered that acute myeloid leukaemia (AML) – causes bone marrow to ‘leak’ blood, preventing chemotherapy from being delivered properly. Drugs that reversed bone marrow […]

Boosting immune cell memory to improve vaccines and cancer immunotherapy

Boosting immune cell memory to improve vaccines and cancer immunotherapy

Vaccines and cancer immunotherapies do essentially the same thing: They boost a person’s immune system, better enabling it to fight an offender, be it microbe or malignancy. Both approaches focus on CD8+ T cells, a type of immune cell that can either kill immediately or commit the offender to “memory,” providing long-term protection. In mouse […]

Cancer patients could get living ‘avatars’ to help treat their tumours, says new study

Cancer patients could get living ‘avatars’ to help treat their tumours, says new study

Cancer patients could be given living ‘avatars’ to enable doctors to test different kinds of drugs to find an effective treatment. Researchers in Portugal said they had demonstrated for the first time that zebrafish larvae could be used as a host for samples of an individual’s tumour. This would allow doctors to try different drugs […]

How Science Is Unlocking The Cancer Medicines Of The Future

How Science Is Unlocking The Cancer Medicines Of The Future

Cancer might still be a word that strikes fear into our hearts, and that’s not surprising. According to the latest statistics from Cancer Research UK, there were 356,860 new cases of cancer diagnosed in 2014, and 163,444 deaths from cancer. But the outlook for patients has never looked better, largely thanks to the prospect of truly game-changing […]

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