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Lung cancer drug resistance explained by computer simulations

Lung cancer drug resistance explained by computer simulations

Scientists from the Universities of Bristol and Parma, Italy, have used molecular simulations to understand resistance to osimertinib — an anticancer drug used to treat types of lung cancer. Osimertinib binds tightly to a protein, epidermal growth factor receptor (EGFR), which is overexpressed in many tumours. EGFR is involved in a pathway that signals for […]

Light-activated Cancer Drugs Without Toxic Side Effects: Fresh Insight

Light-activated Cancer Drugs Without Toxic Side Effects: Fresh Insight

Future cancer drugs that are activated by light and don’t cause the toxic side-effects of current chemotherapy treatments are closer to becoming a reality, thanks to new research made possible by the Monash Warwick Alliance, an intercontinental collaboration between the University of Warwick (UK) and Monash University (Australia). Led by Robbin Vernooij, a joint PhD […]

How Cancer Metastasis Happens: Researchers Reveal a Key Mechanism

How Cancer Metastasis Happens: Researchers Reveal a Key Mechanism

Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center researchers. How metastasis occurs has been one of the central mysteries […]

Remote-controlled cancer immunotherapy system

Remote-controlled cancer immunotherapy system

A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells. There is a critical need to non-invasively and remotely manipulate cells at a distance, particularly for translational applications in animals and humans, researchers said. The […]

More than just ‘chemo brain’: Cancer impacts memory, too

More than just ‘chemo brain’: Cancer impacts memory, too

People undergoing cancer treatment often report experiencing “chemo brain,” or states of confusion and cognitive impairment due to aggressive chemotherapy treatment. But new research suggests that these cognitive problems might start earlier, with the development of cancer tumors. Researchers at the Baycrest Centre for Geriatric Care in Toronto, Canada, conducted a study focusing on the […]

Researchers Build a Cancer Immunotherapy Without Immune Cells

Researchers Build a Cancer Immunotherapy Without Immune Cells

Engineering an immune cell to recognize and kill a cancer cell is the key to chimeric antigen receptor (CAR) T-cell therapy, but modified immune cells also have the potential to cause problems for patients. One such complication, cytokine release syndrome, is an overreaction of the immune system that can cause symptoms as mild as a fever […]

Gut microbiome may make chemo drug toxic to patients

Gut microbiome may make chemo drug toxic to patients

Albert Einstein College of Medicine researchers report that the composition of people’s gut bacteria may explain why some of them suffer life-threatening reactions after taking a key drug for treating metastatic colorectal cancer. The findings, described online in npj Biofilms and Microbiomes, a Nature research journal, could help predict which patients will suffer side effects and […]

Gut bacteria ‘boost’ cancer therapy

Gut bacteria ‘boost’ cancer therapy

Bacteria living in the murky depths of the digestive system seem to influence whether tumors shrink during cancer therapy, say French and US researchers. They tested the microbiome – the collection of microscopic species that live in us – in cancer patients. Two studies, in the journal Science, linked specific species and the overall diversity […]

How bacteria hinder chemotherapy

How bacteria hinder chemotherapy

To the reasons that chemotherapy sometimes does not work, we can now add one more: bacteria. In a study published in Science, researchers describe findings that certain bacteria can be found in human pancreatic tumors. The findings further showed that some of these bacteria contain an enzyme that inactivates a common drug used to treat various […]

Promising immunotherapy drug now available for some lung cancer patients in England

Promising immunotherapy drug now available for some lung cancer patients in England

Some lung cancer patients in England can now be offered a potentially life-extending immunotherapy drug. The National Institute for Health and Care Excellence (NICE) has said that nivolumab (Opdivo) should be made available to certain lung cancer patients in England through the Cancer Drugs Fund (CDF). Rose Gray, Cancer Research UK’s senior policy adviser, welcomed the decision […]

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