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Promising immunotherapy drug now available for some lung cancer patients in England

Promising immunotherapy drug now available for some lung cancer patients in England

Some lung cancer patients in England can now be offered a potentially life-extending immunotherapy drug. The National Institute for Health and Care Excellence (NICE) has said that nivolumab (Opdivo) should be made available to certain lung cancer patients in England through the Cancer Drugs Fund (CDF). Rose Gray, Cancer Research UK’s senior policy adviser, welcomed the decision […]

Chemo-boosting drug discovered for leukaemia

Chemo-boosting drug discovered for leukaemia

Drugs developed to treat heart and blood vessel problems could be used in combination with chemotherapy to treat an aggressive form of adult leukaemia. Researchers at the Francis Crick Institute, King’s College London and Barts Cancer Institute discovered that acute myeloid leukaemia (AML) – causes bone marrow to ‘leak’ blood, preventing chemotherapy from being delivered properly. Drugs that reversed bone marrow […]

Boosting immune cell memory to improve vaccines and cancer immunotherapy

Boosting immune cell memory to improve vaccines and cancer immunotherapy

Vaccines and cancer immunotherapies do essentially the same thing: They boost a person’s immune system, better enabling it to fight an offender, be it microbe or malignancy. Both approaches focus on CD8+ T cells, a type of immune cell that can either kill immediately or commit the offender to “memory,” providing long-term protection. In mouse […]

Cancer patients could get living ‘avatars’ to help treat their tumours, says new study

Cancer patients could get living ‘avatars’ to help treat their tumours, says new study

Cancer patients could be given living ‘avatars’ to enable doctors to test different kinds of drugs to find an effective treatment. Researchers in Portugal said they had demonstrated for the first time that zebrafish larvae could be used as a host for samples of an individual’s tumour. This would allow doctors to try different drugs […]

How Science Is Unlocking The Cancer Medicines Of The Future

How Science Is Unlocking The Cancer Medicines Of The Future

Cancer might still be a word that strikes fear into our hearts, and that’s not surprising. According to the latest statistics from Cancer Research UK, there were 356,860 new cases of cancer diagnosed in 2014, and 163,444 deaths from cancer. But the outlook for patients has never looked better, largely thanks to the prospect of truly game-changing […]

Shedding light on cause of resistance to tumor immunotherapy

Shedding light on cause of resistance to tumor immunotherapy

In tumor immunotherapy, the body’s own defense system is activated against the tumor cells. However, for the majority of patients, the tumor cells become resistant to the treatments used. Researchers at the University of Zurich and the University Hospital Zurich have now found in skin cutaneous melanoma that an epigenetic control protein is key to […]

Concurrent chemotherapy, proton therapy improves survival in patients with advanced lung cancer

Concurrent chemotherapy, proton therapy improves survival in patients with advanced lung cancer

For patients with advanced, inoperable stage 3 lung cancer, concurrent chemotherapy and the specialized radiation treatment, proton therapy, offers improved survival compared to historical data for standard of care, according to a new study from The University of Texas MD Anderson Cancer Center. The research, published in JAMA Oncology, reported an overall survival (OS) of 26.5 months. In […]

Key to improved cancer immunotherapy

Key to improved cancer immunotherapy

Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) have investigated how different subtypes of essential immune-response cells called CD8+ T lymphocytes cooperate to mount a stronger anti-tumor response. The results show that generation of an optimal immune response to cancer requires cooperation between two types of memory T cell — one circulating […]

New way to tackle cancer cells

New way to tackle cancer cells

In-situ assembly of amphiphilic peptides with accompanying cellular functions inside a living cell (i.e., intracellular assembly) and their interaction with cellular components have been emerging as a versatile strategy in controlling cellular fate. However, achieving spatiotemporal control (i.e., inside cellular organelles or other sub-compartments) over the self-assembly of synthetic molecules inside the cell is challenging […]

Better use of current drugs to target cancer

Better use of current drugs to target cancer

A team of researchers at McMaster University has identified a unique feature of cancer stem cells that can be exploited to kill the deadly cells thought to be the reason that cancer comes back after therapy. Understanding this feature will be useful for delivering more targeted cancer therapeutics to the right patients. The study, published […]

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